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Title: Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study
Authors: Pye, Stephen R ×
Almusalam, Bader
Boonen, Steven
Vanderschueren, Dirk
Borghs, Herman
Gielen, Evelien
Adams, Judith E
Ward, Kate A
Bartfai, Gyorgy
Casanueva, Felipe F
Finn, Joseph D
Forti, Gianni
Giwercman, Aleksander
Huhtaniemi, Ilpo T
Kula, Krzysztof
Labrie, Fernand
Lean, Michael E J
Pendleton, Neil
Punab, Margus
Silman, Alan J
Wu, Frederick C W
O'Neill, Terence W
The EMAS Study Group #
Issue Date: Apr-2011
Publisher: Springer-Verlag
Series Title: Calcified Tissue International vol:88 issue:6 pages:503-510
Abstract: The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study (EMAS). Subjects were invited by letter to complete a postal questionnaire and to attend for an interviewer-assisted questionnaire, quantitative ultrasound (QUS) of the calcaneus, and a fasting blood sample from which serum levels of IGFBP-1, IGFBP-3, IGF-I, estradiol (E(2)), and SHBG were assayed. The questionnaires included the Physical Activity Scale for the Elderly (PASE) and questions about smoking and alcohol consumption. Estimated bone mineral density (eBMD) was derived as a function of the QUS parameters speed of sound and broadband ultrasound attenuation. Height and weight were measured in all subjects. 3057 men, mean age 59.7 years (standard deviation 11.0) were included in the analysis. After adjusting for age, center, and BMI, higher levels of IGFBP-1 were associated with lower eBMD. Higher levels of both IGFBP-3 and IGF-I were associated with higher eBMD. After further adjustment for PASE score, current smoking, alcohol consumption, free E(2), and SHBG, IGFBP-3 and IGF-I, though not IGFBP-1, remained significantly associated with eBMD. IGFBP-1 was associated with bone health, though the effect could be explained by other factors. IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men.
ISSN: 0171-967X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gerontology and Geriatrics
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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