Title: Potamopholide, a new sesquiterpene lactone from Vernonia potamophila
Authors: Kilonda, Amuri ×
Mihigo, S
Lohohola, O
Tshibey, TS
Compernolle, Frans
Toppet, Suzanne
Hoornaert, GJ #
Issue Date: Jan-2003
Publisher: Wiley-v c h verlag gmbh
Series Title: European journal of organic chemistry issue:1 pages:123-127
Abstract: A new sesquiterpene lactone, named potamopholide, was isolated along with the known triterpene lupeol from the leaves of Vernonia potamophila. The stereochemical structure of the new compound, (3R*,4S*,5E,8S*,10S*)-3,8-epoxy-3,4,13-trihydroxy-1-oxogermacra-5,7(11)-dien-6,12- olide, was elucidated by mass spectrometric (CIMS, EIMS, HREIMS) and NMR spectroscopic (HMQC, HMBC, NOESY) analyses and by comparison with closely related compounds. The analysis was confirmed by MM+ geometry optimisation of the conformational structure. This 3,8-O-bridged 10-membered ring hemiacetal seems to be related structurally to known 1,4-O-bridged compounds. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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