Title: Laterality Preference and Cognition: Cross-Syndrome Comparison of Patients with Trisomy 21 (Down), del7q11.23 (Williams-Beuren) and del22q11.2 (DiGeorge or Velo-Cardio-Facial) Syndromes
Authors: Carlier, Michèle ×
Desplanches, Aude Gérard
Philip, Nicole
Stefanini, Silvia
Vicari, Stefano
Volterra, Virginia
Deruelle, Christine
Fisch, Gene
Doyen, Anne Lise
Swillen, Ann #
Issue Date: Apr-2011
Publisher: Kluwer Academic/Plenum Publishers
Series Title: Behavior Genetics vol:41 issue:3 pages:413-422
Abstract: We report on a cross-syndrome comparison of hand, foot, eye and ear laterality in three groups of individuals with different genetic disorders (trisomy 21, del7q11.23, and del22q11.2) to test the relationship between atypical laterality and intellectual disability. These groups were compared to a group of typically developing persons. Hand, foot, eye and ear laterality was assessed using item tasks, conducted twice, and Bishop's card-reaching test. Ordering of the mean IQ score for each of the three groups was as follows: trisomy 21 < del7q11.23 < del22q11.2. We observed the same ordering as for IQ, particularly in mixed handedness, degree of laterality, hand and foot consistency. The existence of a cognitive threshold, below which lateral preference is atypical, advocates for a causal link between cognition and laterality in those with low IQ although unknown other factors underlying both could determine this association.
ISSN: 0001-8244
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Research Group for Adapted Physical Activity and Psychomotor Rehabilitation
× corresponding author
# (joint) last author

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