Title: COMT Val(158) Met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome
Authors: Boot, Erik ×
Booij, Jan
Zinkstok, Janneke R
Baas, Frank
Swillen, Ann
Owen, Michael J
Murphy, Declan G
Murphy, Kieran C
Linszen, Don H
van Amelsvoort, Thérèse A #
Issue Date: 2011
Publisher: Wiley-Liss, Inc.
Series Title: Synapse vol:65 pages:967-970
Article number: 10.1002/syn.20932
Abstract: Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution in striatum is assumed less significant. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in fifteen adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography (SPECT) and the selective D(2/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2/3) R BP(ND) than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders. Synapse, 2011. © 2011 Wiley-Liss, Inc.
ISSN: 0887-4476
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Research Group for Adapted Physical Activity and Psychomotor Rehabilitation
× corresponding author
# (joint) last author

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