Title: Diastereoselective synthesis of trans-fused tetrahydropyran derivatives of 5H-dibenzo[a,d]cycloheptene
Authors: Mao, Hua ×
Koukni, Mohamed
Kozlecki, Tomasz
Compernolle, Frans
Hoornaert, GJ #
Issue Date: Jan-2002
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:43 issue:48 pages:8697-8700
Abstract: The epoxides derived from 5H-dibenzo[a,d]cycloheptene and its 2-fluoro derivative were converted into the trans-fused hydropyran-3-one compounds (4aR*,13bS*)-(12-fluoro-)4,4a,9,13b-tetrahydrodibenzo[3,4:6,7]cyclohepta[1,2-b]pyran-3(2H)-one and the corresponding 3-amino derivative via two separate sequences. These involved opening of the epoxide by either a propargyl or allylmagnesium reagent followed by tungsten-mediated cyclisation of the alkynol or OSO4-catalysed transformation into the diol. (C) 2002 Elsevier Science Ltd. All rights reserved.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science