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Title: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Authors: Schunkert, Heribert ×
König, Inke R
Kathiresan, Sekar
Reilly, Muredach P
Assimes, Themistocles L
Holm, Hilma
Preuss, Michael
Stewart, Alexandre F R
Barbalic, Maja
Gieger, Christian
Absher, Devin
Chen, Li
Cichon, Sven
Codd, Veryan
Davies, Robert W
Dedoussis, George
Dehghan, Abbas
Demissie, Serkalem
Devaney, Joseph M
Diemert, Patrick
Doering, Angela
Patterson, Chris C
Eifert, Sandra
Mokhtari, Nour Eddine El
Ellis, Stephen G
Elosua, Roberto
Engert, James C
Epstein, Stephen E
de Faire, Ulf
Fischer, Marcus
Folsom, Aaron R
Freyer, Jennifer
Peters, Annette
Gigante, Bruna
Girelli, Domenico
Gretarsdottir, Solveig
Gudnason, Vilmundur
Gulcher, Jeffrey R
Halperin, Eran
Hammond, Naomi
Hazen, Stanley L
Hofman, Albert
Horne, Benjamin D
Peyvandi, Flora
Illig, Thomas
Iribarren, Carlos
Jones, Gregory T
Jukema, J Wouter
Kaiser, Michael A
Kaplan, Lee M
Kastelein, John J P
Khaw, Kay-Tee
Knowles, Joshua W
Kolovou, Genovefa
Qu, Liming
Kong, Augustine
Laaksonen, Reijo
Lambrechts, Diether
Leander, Karin
Lettre, Guillaume
Lieb, Wolfgang
Loley, Christina
Lotery, Andrew J
Mannucci, Pier M
Maouche, Seraya
Quyyumi, Arshed A
Martinelli, Nicola
McKeown, Pascal P
Meisinger, Christa
Meitinger, Thomas
Melander, Olle
Merlini, Pier Angelica
Mooser, Vincent
Morgan, Thomas
Mühleisen, Thomas W
Muhlestein, Joseph B
Rader, Daniel J
Münzel, Thomas
Musunuru, Kiran
Nahrstaedt, Janja
Nelson, Christopher P
Nöthen, Markus M
Olivieri, Oliviero
Patel, Riyaz S
Rallidis, Loukianos S
Rice, Catherine
Rosendaal, Frits R
Rubin, Diana
Aherrahrou, Zouhair
Salomaa, Veikko
Sampietro, M Lourdes
Sandhu, Manj S
Schadt, Eric
Schäfer, Arne
Schillert, Arne
Schreiber, Stefan
Schrezenmeir, Jürgen
Schwartz, Stephen M
Siscovick, David S
Allayee, Hooman
Sivananthan, Mohan
Sivapalaratnam, Suthesh
Smith, Albert
Smith, Tamara B
Snoep, Jaapjan D
Soranzo, Nicole
Spertus, John A
Stark, Klaus
Stirrups, Kathy
Stoll, Monika
Altshuler, David
Tang, W H Wilson
Tennstedt, Stephanie
Thorgeirsson, Gudmundur
Thorleifsson, Gudmar
Tomaszewski, Maciej
Uitterlinden, Andre G
van Rij, Andre M
Voight, Benjamin F
Wareham, Nick J
Wells, George A
Anand, Sonia S
Wichmann, H-Erich
Wild, Philipp S
Willenborg, Christina
Witteman, Jaqueline C M
Wright, Benjamin J
Ye, Shu
Zeller, Tanja
Ziegler, Andreas
Cambien, Francois
Goodall, Alison H
Andersen, Karl
Cupples, L Adrienne
Quertermous, Thomas
März, Winfried
Hengstenberg, Christian
Blankenberg, Stefan
Ouwehand, Willem H
Hall, Alistair S
Deloukas, Panos
Thompson, John R
Stefansson, Kari
Anderson, Jeffrey L
Roberts, Robert
Thorsteinsdottir, Unnur
O'Donnell, Christopher J
McPherson, Ruth
Erdmann, Jeanette
CARDIoGRAM Consortium
Samani, Nilesh J
Ardissino, Diego
Ball, Stephen G
Balmforth, Anthony J
Barnes, Timothy A
Becker, Diane M
Becker, Lewis C
Berger, Klaus
Bis, Joshua C
Boekholdt, S Matthijs
Boerwinkle, Eric
Braund, Peter S
Brown, Morris J
Burnett, Mary Susan
Buysschaert, Ian
Cardiogenics
Carlquist, John F #
Issue Date: Apr-2011
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:43 issue:4 pages:333-U153
Abstract: We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
URI: 
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Department of Materials Engineering - miscellaneous
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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