Title: Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Authors: Skerlj, Renato ×
Bridger, Gary
Zhou, Yuanxi
Bourque, Elyse
Langille, Jonathan
Fluri, Maria Di
Bogucki, David
Yang, Wen
Wang, Letian
Nan, Susan
Baird, Ian
Metz, Markus
Darkes, Marilyn
Labrecque, Jean
Lau, Gloria
Fricker, Simon
Huskens, Dana
Schols, Dominique #
Issue Date: Apr-2011
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:21 issue:8 pages:2450-2455
Abstract: A novel series of CCR5 antagonists were identified based on the redesign of Schering C. An SAR was established based on inhibition of CCR5 (RANTES) binding and these compounds exhibited potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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