Title: Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line
Authors: Buckley, Shannon ×
Ulloa Montoya, Fernando
Abts, David
Oostendorp, Robert A J
Dzierzak, Elaine
Ekker, Stephen C
Verfaillie, Catherine #
Issue Date: Jan-2011
Publisher: Springer-Verlag
Series Title: Experimental Hematology vol:39 issue:1 pages:114-123
Abstract: The microenvironment wherein hematopoietic stem cells (HSC) reside orchestrates HSC self-renewal vs. differentiation decisions. Stromal cells derived from ontogenically divergent hematopoietic microenvironments can support HSC in vitro and have been used to decipher factors that influence HSC fate decisions. Employing stromal cell lines derived from the aorta-gonad-mesonephros and embryonic liver, we aim to identify secreted factors that maintain/expand HSC in vitro.
ISSN: 0301-472X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartemental Stem Cell Institute (-)
× corresponding author
# (joint) last author

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