Title: Oct4-negative multipotent adult progenitor cells and mesenchymal stem cells as regulators of T-cell alloreactivity in mice
Authors: Luyckx, Ariane ×
De Somer, Lien
Jacobs, Sandra
Rutgeerts, Omer
Lenaerts, Caroline
Roobrouck, Valerie
Verfaillie, Catherine
Waer, Mark
Van Gool, Stefaan
Billiau, An #
Issue Date: Jun-2011
Publisher: Elsevier/North-Holland Biomedical Press
Series Title: Immunology Letters vol:137 issue:1-2 pages:78-81
Abstract: Multipotent adult progenitor cells (MAPC) are clinically being explored as an alternative to mesenchymal stem cells (MSC) for the immunomodulatory control of graft-versus-host disease (GvHD). Here, we performed an explorative study of the immunomodulatory potential of mouse MAPC (mMAPC), in comparison with that of MSC (mMSC) using experimental models of T-cell alloreactivity. Suppressive effects of Oct4-expressing mMAPC have been described previously; here, we studied mMAPC expressing low to no Oct4 ('mClone-3'), recently shown to be most representative for the human MAPC counterpart. mClone-3 and mMSC exhibited similar immunophenotype and in vitro immunogenic behavior. Allogeneic T-cell↔dendritic cell-proliferation assays showed strong dose-dependent T-cell-suppressive effects of both mClone-3 and mMSC. In a popliteal lymph node assay, mClone-3 and mMSC equally suppressed in vivo alloreactive T-cell expansion. We conclude that mouse MAPC and MSC exhibit similar immunosuppressive behavior in in vitro and local in vivo GvHD assays.
ISSN: 0165-2478
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartemental Stem Cell Institute (-)
Laboratory of Experimental Transplantation
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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