Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C
Marcellin, Patrick × Forns, Xavier Goeser, Tobias Ferenci, Peter Nevens, Frederik Carosi, Giampiero Drenth, Joost P Serfaty, Lawrence De Backer, Koen Van Heeswijk, Rolf Luo, Donghan Picchio, Gaston Beumont, Maria #
Gastroenterology vol:140 issue:2 pages:459-U159
Recent studies have shown that 12 weeks of treatment with telaprevir, administered every 8 hours (q8h), combined with pegylated interferon (peginterferon) alfa-2a plus ribavirin significantly increased the rate of hepatitis C virus (HCV) eradication (sustained virologic response [SVR]) in patients infected with HCV genotype 1 compared with approved therapy. We investigated the efficacy, safety, tolerability, and pharmacokinetics of telaprevir given q8h or every 12 hours (q12 h) in combination with peginterferon alfa-2a or alfa-2b.