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Title: Incorporation of an indole-containing diarylbutylamine pharmacophore into furo[2,3-a]carbazole ring systems
Authors: Maertens, F ×
Toppet, Suzanne
Hoornaert, GJ
Compernolle, Frans #
Issue Date: Jan-2005
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:61 issue:7 pages:1715-1722
Abstract: Due to concurrent oxidation of the indole moiety in the starting carbazole alkenol, an epoxidation route aiming at incorporation of a conformationally constrained diarylbutylamine failed to give the desired furo[2,3-a]carbazole ring system. Instead, an indole epoxide intermediate was generated, which underwent rearrangement involving participation of a vicinal OH group. The required furo[2,3-a]2 carbazole could, however, be accessed via a Hg2+-induced cyclisation of a carbazole alkynol. (C) 2004 Elsevier Ltd. All rights reserved.
URI: 
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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