Title: Contextual conditioning in rats as an animal model for generalized anxiety disorder
Authors: Luyten, Laura
Vansteenwegen, Deb
van Kuyck, Kris
Gabriƫls, Loes
Nuttin, Bart # ×
Issue Date: Jun-2011
Series Title: Cognitive, Affective & Behavioral Neuroscience vol:11 issue:2 pages:228-244
Abstract: Animal models of psychiatric disorders are important translational tools for exploring new treatment options and gaining more insight into the disease. Thus far, there is no systematically validated animal model for generalized anxiety disorder (GAD), a severely impairing and difficult-to-treat disease. In this review, we propose contextual conditioning (CC) as an animal model for GAD. We argue that this model has sufficient face validity (there are several symptom similarities), predictive validity (it responds to clinically effective treatments), and construct validity (the underlying mechanisms are comparable). Although the refinement and validation of an animal model is a never-ending process, we want to give a concise overview of the currently available evidence. We suggest that the CC model might be a valuable preclinical tool to enhance the development of new treatment strategies and our understanding of GAD.
ISSN: 1530-7026
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurosurgery and Neuroanatomy
Centre for Psychology of Learning and Experimental Psychopathology
Research Group Psychiatry
× corresponding author
# (joint) last author

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