ITEM METADATA RECORD
Title: Protein dynamics: hydration and cavities
Authors: Heremans, Karel # ×
Issue Date: Jan-2005
Publisher: Assoc bras divulg cientifica
Series Title: Brazilian journal of medical and biological research vol:38 issue:8 pages:1157-1165
Abstract: The temperature-pressure behavior of proteins seems to be unique among the biological macromolecules. Thermodynamic as well as kinetic data show the typical elliptical stability diagram. This may be extended by assuming that the unfolded state gives rise to volume and enthalpy-driven liquid-liquid transitions. A molecular interpretation follows from the temperature and the pressure dependence of the hydration and cavities. We suggest that positron annihilation spectroscopy can provide additional quantitative evidence for the contributions of cavities to the dynamics of proteins. Only mature amyloid fibrils that form from unfolded proteins are very resistant to pressure treatment.
URI: 
ISSN: 0100-879X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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