Title: Anti-CD20 monoclonal antibodies and their use in adult autoimmune hematological disorders
Authors: Dierickx, Daan ×
Delannoy, André
Saja, Khalid
Verhoef, Gregor
Provan, Drew #
Issue Date: Mar-2011
Publisher: Wiley-Liss, Inc.
Series Title: American Journal of Hematology vol:86 issue:3 pages:278-291
Article number: 10.1002/ajh.21939
Abstract: Autoimmune hematological disorders encompass a broad group of hematological conditions characterized by the loss of self-tolerance to a variety of antigens. Despite good response to first-line therapy in the majority of patients, relapses are common, necessitating new and safe therapeutic options. The anti-CD20 monoclonal antibody rituximab has led to substantial improvement in the treatment of malignant and immune-mediated disorders involving B cells. Although experience with rituximab in immune-mediated hematological disorders is rarely supported by randomized trials, there is now substantial experience with rituximab suggesting that anti-CD20 therapy is an effective and well-tolerated alternative to immunosuppressive therapy in these disorders. However, caution is needed based on recent reports describing-sometimes severe-rituximab-related complications. Am. J. Hematol. 2011. © 2011 Wiley-Liss, Inc.
ISSN: 0361-8609
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
× corresponding author
# (joint) last author

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