The Y238X Stop Codon Polymorphism in the Human beta-Glucan Receptor Dectin-1 and Susceptibility to Invasive Aspergillosis
Chai, Louis Y. A × de Boer, Mark G. J van der Velden, Walter J. F. M Plantinga, Theo S van Spriel, Annemiek B Jacobs, Cor Halkes, Constantijn J. M Vonk, Alieke G Blijlevens, Nicole M van Dissel, Jaap T Donnelly, Peter J Kullberg, Bart-Jan Maertens, Johan Netea, Mihai G #
Published by the University of Chicago Press for the Infectious Diseases Society of America
The Journal of Infectious Diseases vol:203 issue:5 pages:736-743
Methods. Association of Dectin-1 Y238X polymorphism with occurrence and clinical course of IA was evaluated in 71 patients who developed IA post hematopoietic stem cell transplantation (HSCT) and in another 21 non-HSCT patients with IA. The control group consisted of 108 patients who underwent HSCT. Functional studies were performed to investigate consequences of the Y238X Dectin-1 polymorphism.