Journal of Periodontology vol:82 issue:10 pages:1478-1482
Background: Microgravity is associated with an increase in peroxidative damage. The effect is more pronounced after long duration space flights and can even last for several weeks after landing. Objectives: To determine the influence of simulated microgravity on the periodontal status and the salivary and serum oxidant/antioxidant status of the body in simulated microgravity (-6° head-down-tilt (HDT) bed rest). Materials and methods: Twenty healthy male volunteers were studied before and after 2 months (60 days) of simulated microgravity (-6° head-down-tilt (HDT) bed rest). We measured the salivary and serum oxidative markers such as Malonaldehyde, 8-hydroxydeoxyguanosine, vitamin C and E and clinical periodontal parameters (probing pocket depth and clinical attachment level). Results: The serum and salivary Vitamin C and E concentrations were significantly decreased while MDA and 8-OHdG levels were significantly increased after 60 days of simulated microgravity. Serum and salivary markers showed a strong and significant correlation. Clinical attachment levels and probing depth were higher but not statistically significant in simulated microgravity. Conclusions: This study suggests that microgravity environment oxidative stress is increased but does not significantly influence the periodontal parameters after 2 months.Also , this study indicate that the possibility that their findings may have a broader clinical relevance to patients on bedrest or physically inactive. Studies on a larger patient samples follow up for a longer time are required to verify the relation between antioxidant status in space microgravity condition and periodontal health.