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Title: Identification of a bacterial inhibitor against g-type lysozyme
Authors: Vanderkelen, Lise ×
Van Herreweghe, Joris
Vanoirbeek, K G A
Baggerman, Geert
Myrnes, B
Declerck, Paul
Nilsen, I. W
Michiels, C. W ×
Callewaert, Lien #
Issue Date: Mar-2011
Publisher: Birkhäuser Verlag
Series Title: Cellular and Molecular Life Sciences vol:68 issue:6 pages:1053-1064
Abstract: Lysozymes are antibacterial effectors of the innate immune system in animals that hydrolyze peptidoglycan. Bacteria have evolved protective mechanisms that contribute to lysozyme tolerance such as the production of lysozyme inhibitors, but only inhibitors of chicken (c-) and invertebrate (i-) type lysozyme have been identified. We here report the discovery of a novel Escherichia coli inhibitor specific for goose (g-) type lysozymes, which we designate PliG (periplasmic lysozyme inhibitor of g-type lysozyme). Although it does not inhibit c- or i-type lysozymes, PliG shares a structural sequence motif with the previously described PliI and MliC/PliC lysozyme inhibitor families, suggesting a common ancestry and mode of action. Deletion of pliG increased the sensitivity of E. coli to g-type lysozyme. The existence of inhibitors against all major types of animal lysozyme and their contribution to lysozyme tolerance suggest that lysozyme inhibitors may play a role in bacterial interactions with animal hosts.
URI: 
ISSN: 1420-682X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Food and Microbial Technology
Microbial and Molecular Systems - miscellaneous
Laboratory for Pharmaceutical Biology (-)
× corresponding author
# (joint) last author

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