Title: Platelet physiology and antiplatelet agents
Authors: Thijs, Tim ×
Nuyttens, Benedicte
Deckmyn, Hans
Broos, Katleen #
Issue Date: Dec-2010
Publisher: Walter de Gruyter
Series Title: Clinical Chemistry and Laboratory Medicine vol:48 pages:S3-S13
Abstract: Apart from the central beneficial role platelets play in hemostasis, they are also involved in atherothrombotic diseases. Here, we review the current knowledge of platelet intracellular signal transduction pathways involved in platelet adhesion, activation, amplification of the activation signal and aggregation, as well as pathways limiting platelet aggregation. A thorough understanding of these pathways allows explanation of the mechanism of action of existing antiplatelet agents, but also helps to identify targets for novel drug development. Clin Chem Lab Med 2010;48:S3-13.
ISSN: 1434-6621
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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