Title: Platelet adhesion to collagen
Authors: Nuyttens, Benedicte ×
Thijs, Tim
Deckmyn, Hans
Broos, Katleen #
Issue Date: Jan-2011
Publisher: Pergamon Press
Series Title: Thrombosis Research vol:127 pages:S26-S29
Abstract: Platelets play a central role in maintaining hemostasis mainly by binding to subendothelial collagen exposed upon vascular injury, thereby initiating thrombus formation. Platelets can bind directly to the exposed collagen through two major receptors i.e. the integrin alpha 2 beta 1 and glycoprotein (GP) VI. However, under high shear conditions the GPIb-V-IX receptor complex and its main ligand von Willebrand Factor are additionally needed for firm platelet adhesion to the vessel wall. In this review, we summarize the current knowledge on the individual roles and structure-function relationships of these main platelet adhesion receptors. (C) 2010 Elsevier Ltd. All rights reserved.
ISSN: 0049-3848
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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