The major obstacles for modelling flood processes in karst areas are a lack of understanding and model representations of the distinctive features and processes associated with runoff generation and often a paucity of field data. In this study, a distributed flood-modelling approach, WetSpa, is modified and applied to simulate the hydrological features and processes in the karst Suoimuoi catchment in northwest Vietnam. With input of topography, land use and soil types in a GIS format, the model is calibrated based on 15 months of hourly meteorological and hydrological data, and is used to Simulate both fast surface and conduit flows, and groundwater discharges from karst and non-karst aquifers. Considerable variability in the simulation accuracy is found among storm events and within the catchment. The simulation results show that the model is able to represent reasonably well the stormflows generated by rainfall events in the study catchment.