Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, first-detected atrial fibrillation, antiarrhythmic, angiotensin, atrial remodelling, LEFT-VENTRICULAR DYSFUNCTION, ACUTE MYOCARDIAL-INFARCTION, CONGESTIVE-HEART-FAILURE, ELECTRICAL CARDIOVERSION, LONG-TERM, FOLLOW-UP, SINUS RHYTHM, CATHETER ABLATION, UNITED-STATES, RISK-FACTORS, Anti-Arrhythmia Agents, Atrial Fibrillation, Cardiac Pacing, Artificial, Heart Rate, Humans, Secondary Prevention, Sinoatrial Node, 1103 Clinical Sciences, Cardiovascular System & Hematology, 3201 Cardiovascular medicine and haematology, 3202 Clinical sciences

Abstract:

Atrial fibrillation (AF) is associated with impaired functional capacity and quality of life and significant morbidity and mortality. The current management approach fails to maintain stable sinus rhythm (SR) in the majority of patients. For many years, guidelines have recommended antiarrhythmic treatment of a first AF episode only if the AF is poorly tolerated, a position that has been reinforced by studies showing no mortality or morbidity advantage of rhythm control over rate control. During the last decade, research has shown mechanisms of self-perpetuation of AF based on electrophysiological and structural remodelling induced by AF itself. There is mounting evidence that 'lone' AF is because of a host of factors, some of which may be easily treatable, such as hypertension, sleep apnoea, and obesity, thus allowing secondary prevention at the time of the first episode of AF. According to these concepts, lack of early intervention could be one of the reasons for long-term failure of maintenance of SR. In this position paper, we propose testing the working hypothesis that if an SR maintenance strategy is selected, treatment of AF should commence at the first-detected episode and should be based on a double strategy of SR restoration and aggressive treatment of associated conditions that promote atrial remodelling.