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Title: Fluorescence in situ hybridization analysis of 110 hematopoietic disorders with chromosome 5 abnormalities: do de novo and therapy-related myelodysplastic syndrome-acute myeloid leukemia actually differ?
Authors: Lessard, M ×
Hélias, C
Struski, S
Perrusson, N
Uettwiller, F
Mozziconacci, M-J
Lafage-Pochitaloff, M
Dastugue, N
Terré, C
Brizard, F
Cornillet-Lefebvre, P
Mugneret, F
Barin, C
Herry, A
Luquet, I
Desangles, F
Michaux, Lucienne
Verellen-Dumoulin, C
Perrot, C
Van den Akker, J
Lespinasse, J
Eclache, V
Berger, R
Groupe Francophone de Cytogénétique Hématologique #
Issue Date: Jul-2007
Publisher: Elsevier Science Pub. Co.
Series Title: Cancer Genetics and Cytogenetics vol:176 issue:1 pages:1-21
Abstract: A retrospective cytogenetic study of acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS) was conducted by the Groupe Francophone de Cytogénétique Hématologique (GFCH) to evaluate the structural abnormalities of chromosome 5 associated with other chromosomal abnormalities, in particular of chromosome 7, in these pathologies. In all, 110 cases of AML/MDS were recruited based on the presence of chromosome 5 abnormalities under conventional cytogenetics and supplemented by a systematic fluorescence in situ hybridization study of chromosomes 5 and 7. The abnormalities of the long arm of chromosome 5 (5q) were deletions of various sizes and sometimes cryptic. The 5q abnormalities were associated with translocations in 54% of cases and were simple deletions in 46%. In 68% of cases, 5q deletions were associated with chromosome 7 abnormalities, and 90% of these presented a complex karyotype. Of the 110 patients, 28 had a hematopoietic disorder secondary to chemotherapy, radiotherapy, or both. Among 82 patients with de novo AML/MDS, 63 were older than 60 years. Chromosomal abnormalities often associated hypodiploidy and chromosome 5 and 7 abnormalities in complex karyotypes, features resembling those of secondary hemopathies. Systematic investigation of the exposure to mutagens and oncogenes is thus essential to specify the factors potentially involved in MDS/AML with 5q abnormalities.
URI: 
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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