Title: Acute megakaryoblastic leukemia and loss of the RUNX1 gene
Authors: Berger, Roland ×
Busson, Maryvonne
Dastugue, Nicole
Radford-Weiss, Isabelle
Michaux, Lucienne
Hagemeijer-Hausman, Anne
Quilichini, Benoît
Benattar, Laurence
Bernard, Olivier
Romana, Serge P #
Issue Date: Jan-2006
Publisher: Elsevier Science Pub. Co.
Series Title: Cancer Genetics and Cytogenetics vol:164 issue:1 pages:71-3
Abstract: Since the RUNX1 gene contributes to megakaryopoiesis and acquired trisomy 21 is the most frequent numerical chromosome anomaly in acute megakaryoblastic leukemia (AMLK), a systematic study of RUNX1 abnormalities was performed by fluorescence in situ hybridization in AMLK patients. Four abnormalities were detected among 15 patients. One copy of RUNX1 was completeley or partially lost in three patients and translocated onto Xq24 in the fourth. The possible consequences of RUNX1 haploinsufficiency are discussed.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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