Title: The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil
Authors: Everaerts, Wouter *
Gees, Maarten *
Aguiar Alpizar, Yeranddy
Farre, Ricard
Leten, Cindy
Apetrei, Aurelia
Dewachter, Ilse
Van Leuven, Fred
Vennekens, Rudi
De Ridder, Dirk
Nilius, Bernd
Voets, Thomas
Talavera PĂ©rez, Karel # ×
Issue Date: Feb-2011
Publisher: Current Biology Ltd.
Series Title: Current Biology vol:21 issue:4 pages:316-321
Abstract: Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental models to induce pain and inflammation [1, 2]. The noxious effects of MO are currently ascribed to specific activation of the cation channel TRPA1 in nociceptive neurons [3, 4]. In contrast to this view, we show here that the capsaicin receptor TRPV1 has a surprisingly large contribution to aversive and pain responses and visceral irritation induced by MO. Furthermore, we found that this can be explained by previously unknown properties of this compound. First, MO has a bimodal effect on TRPA1, producing current inhibition at millimolar concentrations. Second, it directly and stably activates mouse and human recombinant TRPV1, as well as TRPV1 channels in mouse sensory neurons. Finally, physiological temperatures enhance MO-induced TRPV1 stimulation. Our results refute the dogma that TRPA1 is the sole nocisensor for MO and motivate a revision of the putative roles of these channels in models of MO-induced pain and inflammation. We propose that TRPV1 has a generalized role in the detection of irritant botanical defensive traits and in the coevolution of multiple mammalian and plant species.
ISSN: 0960-9822
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Ion Channel Research
Translational Research in GastroIntestinal Disorders
Department of Human Genetics - miscellaneous
* (joint) first author
× corresponding author
# (joint) last author

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