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Title: The effects of acute citalopram dosing on gastric motor function and nutrient tolerance in healthy volunteers
Authors: Janssen, Pieter
Van Oudenhove, Lukas
Casteels, Cindy
Vos, Rita
Verbeke, Kristin
Tack, Jan # ×
Issue Date: Feb-2011
Publisher: Blackwell Science
Series Title: Alimentary Pharmacology & Therapeutics vol:33 issue:3 pages:395-402
Abstract: BACKGROUND:
It is unclear whether endogenous serotonin release is involved in the regulation of gastric motility and food intake.

AIM:
To study the effect of acute administration of the selective serotonin reuptake inhibitor citalopram on gastric motor function in man.

METHODS:
Nineteen healthy volunteers underwent a gastric barostat, gastric emptying and/or a drinking test after dosing with either placebo or citalopram (20 mg intravenously). In the barostat protocol, a flaccid bag was introduced in the stomach and inflated at intra-abdominal pressure +2 mmHg, volume was recorded before and after administration of a liquid meal (300 kcal). Gastric emptying for solids and liquids was simultaneously assessed using the ¹⁴C-octanoic acid/¹³C-glycine breath test. During the drink test, volunteers drank at a rate of 15 mL/min until maximal satiation. Citalopram was compared with placebo using t-tests and mixed model analysis.

RESULTS:
Citalopram induced a significant preprandial gastric relaxation (volume increase of 154 ± 55 mL vs. -38 ± 33 mL after placebo dosing; P < 0.05), whereas the postprandial volume increase was significantly decreased after citalopram treatment (F₁₂.₈₀ = 4.78, P < 0.0001; maximum volume increase was 304 ± 40 vs. 201 ± 54 mL after placebo and citalopram treatment respectively). Citalopram enhanced solid (123 ± 17 vs. 77 ± 6 min, P < 0.05) but not liquid emptying (62 ± 6 vs. 57 ± 4 min). Satiation scores during the drink test were lower after citalopram (F₁₉.₁₅₃ = 2.02, P = 0.01; volunteers drank 998 ± 129 vs. 765 ± 79 mL after citalopram and placebo treatment respectively).

CONCLUSION:
The observed effects indicate a role for serotonin in the control of gastric motility and food intake.
ISSN: 0269-2813
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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