Title: Identification of epigenetic DNA modifications with a protein nanopore
Authors: Wallace, Emma V. B ×
Stoddart, David
Heron, Andrew J
Mikhailova, Ellina
Maglia, Giovanni
Donohoe, Timothy J
Bayley, Hagan #
Issue Date: 2010
Publisher: Royal Society of Chemistry
Series Title: Chemical Communications vol:46 issue:43 pages:8195-8197
Abstract: Two DNA bases, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (hmC), marks of epigenetic modification, are recognized in immobilized DNA strands and distinguished from G, A, T and C by nanopore current recording. Therefore, if further aspects of nanopore sequencing can be addressed, the approach will provide a means to locate epigenetic modifications in unamplified genomic DNA.
ISSN: 1359-7345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science