Title: Droplet networks with incorporated protein diodes show collective properties
Authors: Maglia, Giovanni ×
Heron, Andrew J
Hwang, William L
Holden, Matthew A
Mikhailova, Ellina
Cheley, Stephen
Bayley, Hagan #
Issue Date: Jul-2009
Publisher: Nature Publishing Group
Series Title: Nature Nanotechnology vol:4 issue:7 pages:437-440
Abstract: Recently, we demonstrated that submicrolitre aqueous droplets submerged in an apolar liquid containing lipid can be tightly connected by means of lipid bilayers(1-5) to form networks(4-6). Droplet interface bilayers have been used for rapid screening of membrane proteins(7,8) and to form asymmetric bilayers with which to examine the fundamental properties of channels and pores(9). Networks, meanwhile, have been used to form microscale batteries and to detect light(4). Here, we develop an engineered protein pore with diode-like properties that can be incorporated into droplet interface bilayers in droplet networks to form devices with electrical properties including those of a current limiter, a half-wave rectifier and a full-wave rectifier. The droplet approach, which uses unsophisticated components (oil, lipid, salt water and a simple pore), can therefore be used to create multidroplet networks with collective properties that cannot be produced by droplet pairs.
ISSN: 1748-3387
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
09 2009 NatNano MAGLIA Diode.pdfMain article Published 1140KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science