Title: Theta-gamma dysrhythmia and auditory phantom perception
Authors: De Ridder, Dirk ×
van der Loo, Elsa
Vanneste, Sven
Gais, Steffen
Plazier, Mark
Kovacs, Silvia
Sunaert, Stefan
Menovsky, Tomas
van de Heyning, Paul #
Issue Date: Apr-2011
Publisher: American Association of Neurological Surgeons
Series Title: Journal of Neurosurgery vol:114 issue:4 pages:912-921
Abstract: Tinnitus is considered an auditory phantom percept analogous to phantom pain. Thalamocortical dysrhythmia has been proposed as a possible pathophysiological mechanism for both tinnitus and pain. Thalamocortical dysrhythmia refers to a persistent pathological resting state theta-gamma coupling that is spatially localized at an area where normally alpha oscillations predominate. Auditory cortex stimulation via implanted electrodes has been developed to treat tinnitus, targeting an area of activation on functional MR imaging elicited by tinnitus-matched sound presentation. The authors describe a case in which clinical improvement was correlated with changes in intracranial recordings. Maximal tinnitus suppression was obtained by current delivery exactly at the blood oxygen level-dependent activation hotspot, which colocalizes with increased gamma and theta activity, in contrast to the other electrode poles, which demonstrated a normal alpha peak. These spectral changes normalized when stimulation induced tinnitus suppression, both on electrode and source-localized electroencephalography recordings. These data suggest that thetagamma coupling as proposed by the thalamocortical dysrhythmia model might be causally related to a conscious auditory phantom percept.
ISSN: 0022-3085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Translational MRI (+)
× corresponding author
# (joint) last author

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