Title: Effect of gender in centrally induced angiotensin II hypertension in dogs
Authors: Doursout, M F ×
Chelly, J E
Wouters, Patrick
Lawrence, C
Liang, Y Y
Buckley, J P #
Issue Date: Feb-1990
Series Title: Hypertension vol:15 issue:2 Suppl pages:I117-20
Abstract: This study was designed to investigate the relation between gender, an endogenous inhibitor of the Na+-K+ pump, and volume-dependent hypertension induced by stimulation of the brain renin-angiotensin system and increased salt intake. Angiotensin II (20 ng/min i.c.v.) was infused for 4 weeks in five dogs of each sex with saline as the drinking fluid. In male dogs, angiotensin II induced parallel pressor (30%) and dipsogenic responses (70%), whereas no hypertension and no increase in fluid intake were observed in females. In contrast, the activity of the Na+-K+ pump as assessed by 86Rb uptake was independent of gender. Our data provide novel evidence that gender plays a determining role in the physiological properties of centrally administered angiotensin II.
ISSN: 0194-911X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Anesthesiology and Algology
× corresponding author
# (joint) last author

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