Title: The effect of compounds related to,penicillin G biosynthesis on the in vitro formation and bioassay of isopenicillin N
Authors: Meesschaert, Boudewijn ×
Alvarez Ruiz, Emilio
Martín, Juan F. #
Issue Date: 1993
Series Title: RUG. Mededelingen van de Faculteit Landbouwwetenschappen vol:58 issue:4b pages:1973-1980
Abstract: L-cysteine, L-cystenyl-L-valine and L-cysteinyl-D-valine showed an apparent inhibition of the isopenicillin N synthase that was due to inactivation of isopenicillin N during bioassay. In contrast to their phenylacetylated analogs (prepared by a new chemical synthesis procedure), these aminothiols caused a concentration and pH-dependent hydrolysis of the beta-lactam ring. Other compounds related to the biosynthetic pathway of the penicillins, such as alpha-aminoadipic acid, phenylacetic acid, L-valine, isopenicillin N, penicillin G, 6-aminopenicillanic acid and their corresponding penicilloic acids did not show any effect on the isopenicillin N synthase of Penicillium chrysogenum.
ISSN: 0035-533X
Publication status: published
KU Leuven publication type: AT
Appears in Collections:Technologiecluster Bioengineering Technologie
Bioengineering Technology TC, Technology Campus Ostend
× corresponding author
# (joint) last author

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