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Title: The use of midazolam versus propofol for short-term sedation following coronary artery bypass grafting
Authors: Snellen, F ×
Lauwers, Peter
Demeyere, Roland
Byttebier, G
Van Aken, H #
Issue Date: Jan-1990
Series Title: Intensive care medicine vol:16 issue:5 pages:312-6
Abstract: Midazolam and propofol were compared in an open randomized study for postoperative sedation during 12 h of mechanical ventilation in 40 patients following coronary artery bypass grafting. After an intravenous loading dose of midazolam (50 or propofol (500, a titrated continuous infusion was administered of midazolam (mean dose 38.1 (SEM 2.6)) or propofol (mean dose 909 (SEM 100)) together with a narcotic analgesic infusion. During mechanical ventilation midazolam and propofol produced a similar quality of sedation, but recovery (midazolam 66 min (SEM 16); propofol 24 min (SEM 7)) and weaning from the ventilator (midazolam 243 min (SEM 44); propofol 154 min (SEM 33)) where faster with propofol. In the 2 groups administration of an intravenous loading dose caused a significant decrease in mean arterial pressure but hemodynamic tolerance during maintenance infusion was good.
ISSN: 0342-4642
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Intensive Care Medicine
Anesthesiology and Algology
× corresponding author
# (joint) last author

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