Title: Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram
Authors: Cassimjee, Naseema ×
Fouche, Jean-Pierre
Burnett, Michael
Lochner, Christine
Warwick, James
Dupont, Patrick
Stein, Dan J
Cloete, Karen J
Carey, Paul D #
Issue Date: Dec-2010
Publisher: Plenum Press
Series Title: Metabolic Brain Disease vol:25 issue:4 pages:369-374
Abstract: It has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety disorder completed magnetic resonance imaging both before and after 12-weeks of treatment with 20 mg/day escitalopram. No increases in structural grey matter were found, but there were decreases in bilateral superior temporal cortex, vermis and the left cerebellum volumes following 12 weeks of treatment with escitalopram. These preliminary findings require replication to determine their reliability, and extension to determine whether or not they are disorder specific.
ISSN: 0885-7490
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Cognitive Neurology
Research Group Experimental Neurology
× corresponding author
# (joint) last author

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