Title: Relationship between computerized morphonuclear image analysis and histopathologic grading of breast cancer
Authors: Larsimont, D ×
Kiss, R
d'Olne, D
de Launoit, Y
Mattheiem, W
Paridaens, Robert
Pasteels, J L
Verhest, A #
Issue Date: Dec-1989
Publisher: Science Printers and Publishers
Series Title: Analytical and Quantitative Cytology and Histology vol:11 issue:6 pages:433-439
Abstract: A pilot study analyzed the relationship between several morphonuclear parameters and the Bloom-Richardson score for 37 invasive, not-otherwise-specified (NOS) ductal breast carcinomas. The SAM-BA 200 cell image processor and its software were used to measure the nuclear features on Feulgen-stained imprint smears. Two parameters representing the numbers of large and dense chromatin clots and two parameters describing the heterogeneity of the chromatin among nuclei in a specimen evolved in a continuous manner parallel with the Bloom-Richardson score from stages NOS-4 to NOS-8. The systematic measurement of these four parameters on a large series of breast cancers may be able to define an objective and reproducible "scale" of differentiation that could be a helpful tool for pathologists and clinicians.
ISSN: 0884-6812
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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