Relationship between computerized morphonuclear image analysis and histopathologic grading of breast cancer
Larsimont, D × Kiss, R d'Olne, D de Launoit, Y Mattheiem, W Paridaens, Robert Pasteels, J L Verhest, A #
Science Printers and Publishers
Analytical and Quantitative Cytology and Histology vol:11 issue:6 pages:433-439
A pilot study analyzed the relationship between several morphonuclear parameters and the Bloom-Richardson score for 37 invasive, not-otherwise-specified (NOS) ductal breast carcinomas. The SAM-BA 200 cell image processor and its software were used to measure the nuclear features on Feulgen-stained imprint smears. Two parameters representing the numbers of large and dense chromatin clots and two parameters describing the heterogeneity of the chromatin among nuclei in a specimen evolved in a continuous manner parallel with the Bloom-Richardson score from stages NOS-4 to NOS-8. The systematic measurement of these four parameters on a large series of breast cancers may be able to define an objective and reproducible "scale" of differentiation that could be a helpful tool for pathologists and clinicians.