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Title: Efficient synthesis of substituted thieno[3,2-e]indoles
Authors: Van Snick, Wim ×
Dehaen, Wim #
Issue Date: Oct-2009
Publisher: Pergamon Press
Series Title: Tetrahedron vol:65 issue:41 pages:8497-8501
Abstract: Efficient cyclization reactions of 5-aminobenzothiophene derivatives with internal and terminal acetylenes, giving 7- and 8-substituted thieno[3,2-e]indoles, are described. The reaction of 4-iodo-5-(methylsulfonamido)benzothiophene with terminal alkynes gave 7-substituted thienoindoles using general Sonogashira reaction conditions. Reaction of 5-amino-4-iodobenzothiophene with internal acetylenes, using Larock's heterocyclization reaction conditions, gave 7,8-disubstituted thieno[3,2-e]indoles. (C) 2009 Elsevier Ltd. All rights reserved.
URI: 
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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