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Title: Identification of a Parasitic Immunomodulatory Protein Triggering the Development of Suppressive M1 Macrophages during African Trypanosomiasis
Authors: Gomez-Rodriguez, Julio ×
Stijlemans, Benoit
De Muylder, Geraldine
Korf, Hannelie
Brys, Lea
Berberof, Magali
Darji, Ayub
Pays, Etienne
De Baetselier, Patrick
Beschin, Alain #
Issue Date: Dec-2009
Publisher: Published by the University of Chicago Press for the Infectious Diseases Society of America
Series Title: The Journal of Infectious Diseases vol:200 issue:12 pages:1849-1860
Abstract: Development of classically activated macrophages (M1 cells) is a prerequisite to controlling parasite growth and therefore resistance to African trypanosomiasis. However, if activation of M1 cells is uncontrolled, including their production of tumor necrosis factor (TNF) and nitric oxide (NO), collateral pathogenic damage to tissues ensues. We report the identification of a novel putative Trypanosoma brucei M1 cell-triggering protein. The recombinant trypanosome-suppressive immunomodulating factor (rTSIF) induced TNF and NO secretion by macrophages. Moreover, M1 cells triggered by rTSIF block T cell proliferation in a manner dependent on NO, interferon g, and cell contact. Furthermore, rTSIF could down-regulate type 2-oriented immune responses. Therefore, trypanosome-suppressive immunomodulating factor (TSIF) may represent a new parasite molecule with the potential to modulate the host immune network, whereby it could contribute to the inflammatory response required to control parasite growth and to the pathogenicity of African trypanosomiasis, including immunosuppression. TSIF knock-down trypanosomes died within 2 days, indicating that TSIF may be essential for parasite biology.
ISSN: 0022-1899
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Faculty of Bioscience Engineering
× corresponding author
# (joint) last author

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