Title: Immunogenicity and protective efficacy of tuberculosis subunit vaccines expressing PPE44 (Rv2770c)
Authors: Romano, Marta ×
Rindi, Laura
Korf, Hannelie
Bonanni, Daniela
Adnet, Pierre-Yves
Jurion, Fabienne
Garzelli, Carlo
Huygen, Kris #
Issue Date: Nov-2008
Publisher: Butterworths
Series Title: Vaccine vol:26 issue:48 pages:6053-6063
Abstract: In this study we have evaluated the vaccine potential of a Mycobacterium tuberculosis antigen of the PPE protein family, namely PPE44 (Rv2770c). PPE44-specific immune responses could be detected in mice acutely, chronically and latently infected with M. tuberculosis. Vaccination of mice with a plasmid DNA vaccine coding for PPE44 or recombinant PPE44 protein formulated ill adjuvant, generated strong cellular and humoral immune responses: immunodominant T cell epitopes were identified. Most importantly, vaccination of mice with both Subunit vaccines followed by an intratracheal challenge with M. tuberculosis resulted in a protective efficacy comparable to the one afforded by BCG. Taken together these results indicate that PPE44 of M. tuberculosis is a protective antigen that Could be included in novel subunit TB vaccines and that warrants further analysis, (C) 2008 Elsevier Ltd. All rights reserved.
ISSN: 0264-410X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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