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Title: IL-15 and IL-15R alpha in CD4(+) T cell immunity
Authors: Van Belle, Tom ×
Grooten, J #
Issue Date: Mar-2005
Publisher: Zakład Narodowy im. Ossolińskich Wydawnictwo Polskiej Adademii Nauk
Series Title: Archivum Immunologiae et Therapiae Experimentalis vol:53 issue:2 pages:115-126
Abstract: The cytokine IL-15 performs numerous functions, such as promotion of growth and Survival, on a plethora of cell types from both the lymphoid and non-lymphoid compartments. Therefore, mice genetically engineered to either lack or overexpress functional IL-15 display reduced immunological responses and leukemia, respectively. Surprisingly, IL-15 protein is hardly found in serum or body fluids. Due to the lack of a clear demonstration of its presence as protein, IL-15 was often referred to as a "ghost cytokine". Recently, however, membrane-bound IL-15 was detected in both a membrane-anchored form and an IL-15R alpha-bound form on monocytes. Interestingly, the latter complex can be transpresented to cells expressing the intermediate-affinity IL-2/15R beta-gamma(C) receptor and thereby support the survival and proliferation of T cells. Moreover, overlapping promoter elements indicate a model of co-regulation of IL-15 and IL-15R alpha by which IL-15 activities are controlled in a cell-contact-dependent manner. In this review, recent reports on IL-15 are combined with previous observations and discussed in terms of their functional consequences for CD4(+) T cell responses.
ISSN: 0004-069X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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