Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice
Sutherland, Andrew P. R * Van Belle, Tom * Wurster, Andrea L Suto, Akira Michaud, Monia Zhang, Dorothy Grusby, Michael J von Herrath, Matthias # ×
American Diabetes Association
Diabetes vol:58 issue:5 pages:1144-1155
OBJECTIVE-Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the pathogenesis of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) mouse strain. The aim of this study was to investigate a causal role for IL-21 in type 1 diabetes.