Title: Regional brain glucose utilization in adenylosuccinase-deficient patients measured by positron emission tomography
Authors: De Volder, A G
Jaeken, Jacques
Van den Berghe, G
Bol, A
Michel, C
Cogneau, M
Goffinet, A M #
Issue Date: Aug-1988
Series Title: Pediatric research vol:24 issue:2 pages:238-42
Abstract: Regional brain glucose utilization was investigated by positron emission tomography with fluorodeoxyglucose in three children with adenylosuccinase deficiency. A consistent pattern was found in the three patients, namely a marked decrease of fluorodeoxyglucose uptake in all gray structures, with the exception of the cerebellum, which was minimally affected. Anomalies predominated in the cerebral cortex, particularly in the anterior regions; they were less pronounced in thalamus and basal ganglia. The observations suggest that positron emission tomography may be a useful tool for the localization of the deleterious effects of metabolic diseases and for the investigation of their pathophysiologic mechanisms.
ISSN: 0031-3998
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Child - Miscellaneous (-)
# (joint) last author

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