Title: The role of G protein-coupled receptors in the pathology of Alzheimer's disease
Authors: Thathiah, Amantha ×
De Strooper, Bart #
Issue Date: Feb-2011
Publisher: Nature Pub. Group
Series Title: Nature Reviews. Neuroscience vol:12 issue:2 pages:73-87
Abstract: G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly influence the amyloid cascade through modulation of the α-, β- and γ-secretases, proteolysis of the amyloid precursor protein (APP), and regulation of amyloid-β degradation. Additionally, amyloid-β has been shown to perturb GPCR function. Emerging insights into the mechanistic link between GPCRs and AD highlight the potential of this class of receptors as a therapeutic target for AD.
ISSN: 1471-003X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for the Research of Neurodegenerative Diseases
× corresponding author
# (joint) last author

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