Title: Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication
Authors: Skerlj, Renato ×
Bridger, Gary
McEachern, Ernest
Harwig, Curtis
Smith, Chris
Kaller, Alan
Veale, Duane
Yee, Helen
Skupinska, Krystyna
Wauthy, Rossana
Wang, Letian
Baird, Ian
Zhu, Yongbao
Burrage, Kate
Yang, Wen
Sartori, Michael
Huskens, Dana
Clercq, Erik De
Schols, Dominique #
Issue Date: Mar-2011
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:21 issue:5 pages:1414-1418
Abstract: A novel series of CXCR4 antagonists were identified based on the substantial redesign of AMD070. These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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