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Title: Antihypertensive therapy in patients above age 60 with systolic hypertension. A progress report of the European Working Party on High Blood Pressure in the Elderly (EWPHE)
Authors: Amery, A ×
Birkenhäger, W
Bogaert, M
Brixko, P
Bulpitt, C
Clement, D
De Leeuw, P
De Plaen, J F
Deruyttere, M
De Schaepdryver, A
Fagard, Robert
Forette, F
Forte, J
Hamdy, R
Hellemans, Jacqueline
Henry, J F
Koistinen, A
Laaser, U
Laher, M
Leonetti, G
Lewis, P
Lund-Johansen, P
MacFarlane, J
Meurer, K
Miguel, P
Morris, J
Mutsers, A
Nissinen, A
O'Brien, E
Ohm, O J
O'Malley, K
Pelemans, Walter
Perera, N
Tuomilehto, J
Verschueren, L J
Willemse, P
Williams, B
Zanchetti, A #
Issue Date: Jan-1982
Series Title: Clinical and experimental hypertension. Part A, Theory and practice vol:4 issue:7 pages:1151-76
Abstract: 1. Although systolic blood pressure elevation is responsible for increased incidence of cardiovascular accidents in old people, the preventive benefit of lowering systolic hypertension in elderly has not been confirmed. 2. A double blind study comparing the effects of a placebo and of an active regimen (hydrochlorothiazide-triamterene with or without methyldopa) in people over 60 years with isolated systolic hypertension has been undertaken by the European Working Party on High blood pressure in the Elderly (EWPHE). 3. The actively treated group shows a lowered sitting blood pressure (-15/6 mm Hg), a mild increase of serum creatine, serum uric acid and blood glucose and a mild decrease of serum potassium after two years of treatment when compared to the spontaneous changes observed in the placebo treated group. 4. The study is continuing to evaluate if the blood pressure reduction prevents or reduces the incidence of cardiovascular accidents, although some biochemical changes were provoked by the treatment.
ISSN: 0730-0077
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
Teacher Training Physics (-)
Gerontology and Geriatrics
× corresponding author
# (joint) last author

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