Title: Discovery of novel anti-HIV active G-quadruplex-forming oligonucleotides
Authors: Di Fabio, Giovanni ×
D'Onofrio, Jennifer
Chiapparelli, Mariateresa
Hoorelbeke, Bart
Montesarchio, Daniela
Balzarini, Jan
De Napoli, Lorenzo #
Issue Date: Feb-2011
Publisher: Royal Society of Chemistry
Series Title: Chemical Communications vol:47 issue:8 pages:2363-5
Abstract: A series of d((5')TGGGAG(3')) sequences, 5'-conjugated with a variety of aromatic groups through phosphodiester linkages, were synthesized, showing CD spectra diagnostic of parallel-stranded, tetramolecular G-quadruplex structures. When tested for anti-HIV-1 and HIV-2 activity, potent inhibition of HIV-1 infection in CEM cell cultures was found, associated with high selectivity index values. Surface Plasmon Resonance assays revealed specific binding to HIV-1 gp120 and gp41.
ISSN: 1359-7345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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