Title: Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors
Authors: Jang, Mi-Yeon
De Jonghe, Steven
Segers, Kenneth
Anné, Jozef
Herdewijn, Piet # ×
Issue Date: Jan-2011
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:19 issue:1 pages:702-714
Abstract: An efficient synthesis of a library of 5-amino-thiazolo[4,5-d]pyrimidines is reported. Regioselective displacements of chlorines, as well as regioselective diazotation reactions are described, which allow the introduction of structural diversity on the scaffold by consecutive reactions. Screening of this focused library led to the discovery of SecA inhibitors from Escherichia coli and Staphylococcus aureus.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

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