Title: Proton magnetic resonance spectroscopy in MRI-negative temporal lobe epilepsy
Authors: Connelly, A ×
Van Paesschen, Wim
Porter, DA
Johnson, CL
Duncan, JS
Gadian, DG #
Issue Date: Jul-1998
Publisher: Advanstar Communications
Series Title: Neurology vol:51 issue:1 pages:61-66
Abstract: Objective: To determine the H-1 MRS findings in patients with intractable temporal lobe epilepsy (TLE) who had no detectable abnormality on either qualitative or quantitative MRI. Background: Previous work has indicated that similar to 20% of patients with TLE remain MRI negative after extensive qualitative and quantitative investigation. Single-voxel H-1 MRS provides a means of identifying potentially diffuse disease. Methods: Seven patients with intractable TLE, normal routine MRI, normal hippocampal volumes, and normal hippocampal and amygdala quantitative T2 values underwent single-voxel H-1 MRS of the medial temporal lobes. The results are compared with those from 13 control subjects and 15 patients with evidence of hippocampal sclerosis (HS). Results: The ratio N-acetylaspartate/(choline-creatine + phosphocreatine) was abnormally low in five of the seven MRI-negative patients. In two of these patients, the ratios were low bilaterally. The observed MRS ratios in the MRI-negative group with abnormal EEG were similar to those from temporal lobes ipsilateral to HS, suggesting the presence of widespread or diffuse disease of a similar degree in both groups. Conclusions: These results demonstrate that MRS can provide evidence of temporal lobe abnormalities in TLE patients who show no abnormality on extensive MRI investigation.
ISSN: 0028-3878
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Epilepsy Research
× corresponding author
# (joint) last author

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