Title: Toward Clinical Proteomics on a Next-Generation Sequencing Platform
Authors: Turner, Daniel J ×
Tuytten, Robin
Janssen, Kris
Lammertyn, Jeroen
Wuyts, Jan
Pollet, Jeroen
Eyckerman, Sven
Brown, Clive
Kas, Koen #
Issue Date: Feb-2011
Series Title: Analytical Chemistry vol:83 issue:3 pages:666-670
Abstract: We report the first next generation sequencing (NGS) application to identify and quantify proteins. Customization of protein specific aptamers enabled direct conversion of serum protein information into NGS read outs. The intrinsic ability of aptamer sequencing to highly multiplex protein detection and quantification, together with the prospect of DNA sequencing further evolving into a commodity technology, could constitute the core of a novel, universal diagnostics paradigm.
ISSN: 0003-2700
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Mechatronics, Biostatistics and Sensors (MeBioS)
Medicine Teaching Programs
× corresponding author
# (joint) last author

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