Title: Glucocorticoid receptor binding to defined regions of alpha 2u-globulin genes
Authors: Van Dijck, Patrick ×
Lemaigre, F P
Winderickx, Joris
Rousseau, G G
Verhoeven, Guido #
Issue Date: Dec-1987
Series Title: Biochemical and Biophysical Research Communications vol:149 issue:3 pages:1099-105
Abstract: A DNA-cellulose competition assay was used to study binding of glucocorticoid receptor complexes to two alpha 2u-globulin genes, RAP 01 and RAO 01. Two binding regions were found in RAP 01, one localized between bp -642 and -452, the other between -252 and -118 from the transcriptional initiation site. Only the second region was found in RAO 01. The binding affinity was comparable to that observed using a long terminal repeat fragment of mouse mammary tumor virus. Both regions contain sequences homologous to a 17-bp consensus proposed for the glucocorticoid receptor binding. Therefore, despite evidence that glucocorticoid induction of alpha 2u-globulin may be indirect, a direct action of the receptor in the 5'-upstream region of the genes cannot be excluded.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Clinical and Experimental Endocrinology
Molecular Microbiology and Biotechnology Section - miscellaneous (-)
× corresponding author
# (joint) last author

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