Title: The folding pathway of the cell-cycle regulatory protein p13suc1: clues for the mechanism of domain swapping
Authors: Schymkowitz, Joost ×
Rousseau, Frederic
Irvine, LR
Itzhaki, LS #
Issue Date: Jan-2000
Publisher: Current Biology
Series Title: Structure vol:8 issue:1 pages:89-100
Abstract: Background: The 113-residue alpha+beta protein suc1 is a member of the cyclin-dependent kinase subunit (cks) family of proteins that are involved in regulation of the eukaryotic cell cycle, in vitro, suc1 undergoes domain swapping to form a dimer by the exchange of a C-terminal beta strand. We have analysed the folding pathway of suc1 in order to determine the atomic details of how strand-exchange occurs in vitro and thereby obtain clues as to the possible mechanism and functional role of dimerisation in vivo.
ISSN: 0969-2126
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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