Title: Kit Gene in Endometrial Carcinoma: An Immunohistochemical and Mutational Analysis
Authors: Vandenput, Ingrid
Debiec-Rychter, Maria
Capoen, An
Verbist, Godelieve
Vergote, Ignace
Moerman, Philippe
Amant, Frédéric # ×
Issue Date: Feb-2011
Publisher: Blackwell Scientific Publications
Series Title: International Journal of Gynecological Cancer vol:21 issue:2 pages:203-205
Abstract: OBJECTIVE:: Because the outcome of recurrent disease of endometrial carcinoma is cumbersome, the development of target treatment strategies is critical. We evaluated KIT, a receptor tyrosine kinase, to determine a potential role for imatinib mesylate in the treatment of endometrial carcinoma. MATERIALS AND METHODS:: Immunohistochemical analysis for KIT expression was performed on paraffin sections from 45 patients: 30 primary and 15 recurrent tumors. Fifteen primary cases were available for mutation analysis. RESULTS:: Histopathological distribution of paraffin-embedded tissue was as follows: 30 type I and 15 type II endometrial carcinoma. Histopathological distribution of fresh-frozen tissue was as follows: 8 type I and 7 type II. Cases did not show KIT expression or mutations in mutational hotspot exons of KIT gene. CONCLUSIONS:: On the basis of the absence of KIT expression or mutations, endometrial carcinoma is unlikely to respond to imatinib mesylate.
ISSN: 1048-891X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
Section Woman - Miscellaneous (-)
Gynaecological Oncology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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