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Title: Altered pharmacokinetics of oral flecainide by cimetidine
Authors: Tjandra-Maga, Tikma Budya ×
Van Hecken, Anne
van Melle, P
Verbesselt, René
de Schepper, P J #
Issue Date: Jul-1986
Series Title: British journal of clinical pharmacology vol:22 issue:1 pages:108-10
Abstract: A potential kinetic interaction between cimetidine and flecainide has been studied in eight healthy males receiving flecainide (200 mg) orally on three occasions: before any treatment and on day 2 and day 7 of 8 days' cimetidine maintenance treatment at 1 g daily. Six days pretreatment with cimetidine induced the following changes in flecainide kinetic parameters: average tmax was prolonged from 1.8 h to 3.6 h and total AUC increased significantly from 4779 to 6131 ng ml-1 h. Plasma elimination half-life and renal clearance were not significantly altered. The fraction of flecainide dose excreted unchanged in urine rose significantly from 31 to 38%. The observed interaction can be explained by an increase in bioavailability or, more probably, by a decrease in biotransformation of flecainide in the presence of cimetidine.
ISSN: 0306-5251
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Clinical Pharmacology Centre (-)
× corresponding author
# (joint) last author

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